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Solvent-Free In Situ Self-Nanoemulsifying Dissolving Microneedles for Rapid and Safe Transdermal Treatment of Acute Pain with Plant-Derived Eugenol
Green Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5GC06106G, PaperPeiya Shen, Chengxiang Luo, Jiaqi Liu, Desen Wang, Jianjun Zhang, Mi Tang, Shuai Qian, Yuan Gao, Yuanfeng Wei
Acute pain treatment is often limited by delayed onset and gastrointestinal side effects of NSAIDs, as well as the addiction potential of opioids. Eugenol (EUG), a natural plant-derived compound with...
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DOI: 10.1039/D5GC06106G, PaperPeiya Shen, Chengxiang Luo, Jiaqi Liu, Desen Wang, Jianjun Zhang, Mi Tang, Shuai Qian, Yuan Gao, Yuanfeng Wei
Acute pain treatment is often limited by delayed onset and gastrointestinal side effects of NSAIDs, as well as the addiction potential of opioids. Eugenol (EUG), a natural plant-derived compound with...
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Using green deep eutectic solvents for targeted regeneration to improve the cycle life of spent lithium iron phosphate batteries
DOI: 10.1039/D5GC04838A, PaperJin Wu, Lin Chen, Ruichao Zhu, Yixuan Zhou, Chuqing Cao, Liang Zhu, Jun Zhang
Developing an eco-friendly, recyclable ternary deep eutectic solvent to achieve structural restoration and performance enhancement of waste lithium iron phosphate.
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Green pathways to low-sulfur diesel: advances and challenges in desulfurization technologies
DOI: 10.1039/D5GC04160K, Tutorial ReviewPeiwen Wu, Shaojie Ma, Wenshuai Zhu
Comprehensively reviews HDS and emerging non-HDS methods, highlighting green strategies and future directions for ultra-clean diesel production.
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A Green Chemistry Approach to the Synthesis of an Emerging Drug for the Treatment of Celiac Disease
Green Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5GC05246G, PaperChandler B. Nelson, Kaitlyn M Frieberg, Jordan R Yirak, Max Baumann, Bruce H. Lipshutz
A sustainable synthesis of ZED1227, a new drug for treaCng Celiac disease, is reported. The route avoids waste-generaCng processes resulCng in an overall E-Factor that reflects reliance on technologies that...
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DOI: 10.1039/D5GC05246G, PaperChandler B. Nelson, Kaitlyn M Frieberg, Jordan R Yirak, Max Baumann, Bruce H. Lipshutz
A sustainable synthesis of ZED1227, a new drug for treaCng Celiac disease, is reported. The route avoids waste-generaCng processes resulCng in an overall E-Factor that reflects reliance on technologies that...
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In-situ Growth of Indium-doped Cerium Oxide for Highly Selective Urea Electrosynthesis from Nitrate and Carbon Dioxide
Green Chem., 2025, Accepted Manuscript
DOI: 10.1039/D5GC04834F, PaperYifan Zhou, Shuying Li, Yuxia Jin, Rui Yang, Peng Luo, Changrui Feng, Ziyuan Yang, Abuliti Abudula, Peifen Wang, Wenhao Lian, Guoqing Guan
Urea electrosynthesis through nitrate and carbon dioxide offers a sustainable alternative to traditional energy-intensive Bosch-Meiser process for urea production. This process enables decentralized production using renewable electricity while mitigating two...
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DOI: 10.1039/D5GC04834F, PaperYifan Zhou, Shuying Li, Yuxia Jin, Rui Yang, Peng Luo, Changrui Feng, Ziyuan Yang, Abuliti Abudula, Peifen Wang, Wenhao Lian, Guoqing Guan
Urea electrosynthesis through nitrate and carbon dioxide offers a sustainable alternative to traditional energy-intensive Bosch-Meiser process for urea production. This process enables decentralized production using renewable electricity while mitigating two...
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Chemical recycling of polycarbonate waste into advanced aviation fuel candidates via nickel–oxygen vacancy dual sites
DOI: 10.1039/D5GC04561D, PaperYushuang Huang, Jiawei Xie, Yisong Zhou, Qianqian Song, Yuan Lei, Chang-an Zhou, Chao Wang, Kui Ma, Lei Song, Hairong Yue, Ji-Jun Zou
Cost-effective Ni/CeO2 catalysts with nickel–oxygen vacancy dual sites enable the upcycling of PC waste into advanced aviation fuel-range hydrocarbons and their strong resistance to coke formation ensures stability and reusability.
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Cascade synthesis of diarylamines catalyzed by oxygen-rich and porous carbon
DOI: 10.1039/D5GC05166E, Paper
Open Access 
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Anna Lenarda, Itisha Jain, Aleksi Kaleva, Valtteri Oksanen, Sami Heikkinen, Risto Koivula, Tom Wirtanen, Michele Melchionna, Tao Hu, Juho HelajaPorous activated carbon bearing OH and CO groups, in the presence of a molecular oxidant, catalyzes metal-free cascade synthesis of diarylamines via enamine formation and oxidative aromatization.
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Eco-designed cellulose-reinforced deep eutectic gels with synergistic mechanical strength, ionic conductivity, and freezing tolerance for flexible electronics
DOI: 10.1039/D5GC05362E, PaperXiangyu Lin, Jie Li, Fei Fu, Ziming Zhu, Yuandong Xu, He Liu, Xu Xu
Eco-designed cellulose-reinforced deep eutectic gels with synergistic mechanical strength, ionic conductivity, adhesion and freezing tolerance for flexible electronics.
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Rapid proton transport through a bio-inspired PO4-built protective layer for stabilizing 5-hydroxymethylfurfural conversion at high current densities
DOI: 10.1039/D5GC04249F, PaperWei Ji, Wenjie Zhang, Chen Deng, Yuwei Xiong, Qi Hao, Hao Zhang, Bing Song, Wenlei Zhu, Dekui Shen, Jason Chun-Ho Lam, Richen Lin
PO4 built protective layers form fast proton channels that boost proton-coupled electron transfer while shielding catalysts from proton corrosion, enabling biomimetic electrocatalysts for high current, sustainable biopolymer electrosynthesis.
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Selective hydrodeoxygenation of lignin phenolics to cyclohexanols over low-Ru catalysts
DOI: 10.1039/D5GC04644K, PaperRumin Ma, Xueying Gao, Xiancheng Li, Shuizhong Wang, Guoyong Song
A low-loaded Ru catalyst efficiently and selectively converts a series of lignin-derived phenolics and bio-oil into cyclohexanols in water.
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Electrochemical reconstruction- and electronegativity-induced electron redistribution for activating sulfur atoms of MoOxSy-based materials toward efficient hydrogen evolution
DOI: 10.1039/D5GC03386A, PaperXiao-Yu Yang, Rui-Yuan Li, Zhan Liu, Chun-Mu Guo, Xiao-Yun Li, Cui-Fang Ye, Zhao Deng, Jia-Min Lyu, Ming-Hui Sun, Shen Yu, Yu Li, Yi-Yong Huang, Li-Hua Chen, Kai Liu, Bao-Lian Su, Yi-Long Wang
This work focuses on the development of a strategy for electrochemical reconstruction coupled with electronegativity to synergistically induce electron redistribution for the activation of sulfur atoms in MoOxSy-based materials toward efficient HER.
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Upcycling of polyethylene terephthalate to high-value chemicals by carbonate-interchange deconstruction
DOI: 10.1039/D5GC03354C, Paper
Open Access 
  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Nicholas J. Galan, Isaiah T. Dishner, Bobby G. Sumpter, Vilmos Kertesz, Nabihan B. Abdul Rahman, Felipe Polo-Garzon, Zoriana Demchuk, Tomonori Saito, Jeffrey C. FosterCarbonates enable PET deconstruction to valuable terephthalate products with high selectivity and low solvent demand.
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Low indoor light-driven CO2 conversion into visible C4 bioplastic via homogeneous non-metal-based biohybrids under photoexcitation
DOI: 10.1039/D5GC02437D, PaperWenjing Wang, Mingzhi Zhang, Meng Guo, Jiaxin Wang, Xuelian Wang, Jianheng Yin, Liang Chen, Yaguang Li
A uniformly autotrophic K/O-CN–R. eutropha biohybrid was designed to efficiently convert CO2 into visible C4 bioplastics without the need for any auxiliary agents.
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Bi-doped directional spin-polarised electron injection modulates MBene surface d–d coupling to promote nitrogen reduction kinetics
DOI: 10.1039/D5GC04584C, PaperKun Cheng, Shaobin Li, Qingyu Cheng, Li Zhang, Yufeng Jiang, Fengbo Li, Xiaoqing Lv
Bi doping modulates Fe 3d orbital spin, directionally injecting electrons into Mo via d–d hybridization to adjust the Mo d-band center, enhancing ambient electrocatalytic nitrogen fixation for MBene heterostructure.
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Chemically recyclable, fully biobased polyolefins with performance parity to low-density polyethylene
DOI: 10.1039/D5GC05344G, PaperWei Sun, Yuzhe Pang, Yucheng He, Zhenyang Luo, Puyou Jia, Yonghong Zhou, Ye Sha
We demonstrate a homopolymerization strategy for the controlled synthesis of fully biobased, high-molecular-weight polyolefins. These materials exhibit thermomechanical properties comparable to LDPE while being chemically recyclable.
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Avoiding tomorrow's chemical mistakes today
DOI: 10.1039/D5GC05283A, Perspective
Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jeroen B. Guinée, Martina G. VijverAdvancing SSbD requires an effective and efficient regulatory-based data strategy to improve data availability and quality for safety assessments and LCA; without it, new methods may merely become empty promises that avoid the real issue.
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Lithium extraction from spinel LiMn2O4 with simultaneous preparation of λ-MnO2 under mild conditions using sodium hypochlorite
DOI: 10.1039/D5GC04585A, Paper
Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Yanhui Kong, Yutaro Takaya, Mauricio Córdova-Udaeta, Chiharu TokoroLithium extraction from spinel LiMn2O4 is important because it is both a mainstream LIB cathode and a key precursor for λ-MnO2, which is widely used for selective lithium extraction from brines and seawater.
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The catalytic conversion of fructose to difructose anhydride
DOI: 10.1039/D5GC04714E, Paper
Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Isabel Hortal-Sánchez, Faysal Ibrahim, Edgard A. Lebrón-Rodríguez, Fabiola Y. Rodríguez-Rodríguez, Grace Gooley, Ruining Ma, Matias Alvear, Ive Hermans, Nelson Cardona-MartínezThe production of difructose anhydride (DFA) from fructose under mild conditions, in a green/bio-derived solvent. Crystal structure created with VESTA, J. Appl. Crystallogr., 2011, 44, 1272–1276.
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Metal-free stereoselective C(sp3)–H indolation of N-heterocycles to potent antimicrobial non-canonical tryp–pro hybrids
DOI: 10.1039/D5GC04622J, PaperSubhajit Saha, Soumya Ranjan Bag, Abdul Akhir, Deepanshi Saxena, Rahul Maitra, Sidharth Chopra, Chandan K. Jana
Direct diastereoselective C–H indolations of N-heterocycles under metal and oxidant-free conditions have been developed for one-step access to enantioenriched indolyl N-heterocycles as new antibacterial scaffolds against multidrug-resistant strains.
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An applied machine learning framework for waste lithium-ion battery leaching with integrated preliminary environmental and economic assessment
DOI: 10.1039/D5GC04752H, PaperAndré Nogueira, Filipe H. B. Sosa, Ana C. Dias, João A. P. Coutinho, Nicolas Schaeffer
Data-driven LIB recycling: a new ML framework predicts metal leaching yields and evaluates process sustainability through integrated economic and environmental impact assessments.
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