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Articles from Wiley

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The latest papers in Chemistry Europe
Updated: 13 weeks 3 days ago

<sup>2</sup>H QUOSY 2D-NMR Experiments in Weakly Aligning Systems: From the Conventional to the Ultrafast Approach

7 July, 2020 - 00:00

QUOSY vs. UF-QUOSY : Recording the 2D-NMR in sub-second experimental time is a modern methodological challenge. In this work, three ultrafast 2H QUOSY 2D experiments (ADUF) designed for anisotropic solvents are investigated.

[Articles]
Dr. Boris Gouilleux, Dr. Abdelkrim Meddour, Dr. Philippe Lesot
doi.org/10.1002/cphc.202000336

Scalable and Recyclable Heterogeneous Organo-photocatalysts on Cotton Threads for Organic and Polymer Synthesis

7 July, 2020 - 00:00

Scalable and recyclable heterogeneous organo-photocatalysts were prepared by a straightforward and single-step coupling reaction of eosin Y (EY) with commercial cotton threads. The immobilized EY can be employed for photoinduced organic transformations and reversible deactivation radical polymerization over multiple reaction cycles with well-retained catalytic efficiency.

[Articles]
Yingying Chu, Zixuan Huang, Ruizhe Liu, Prof. Cyrille Boyer, Dr. Jiangtao Xu
doi.org/10.1002/cptc.202000106

From Rare Reagents to Rare Products: Regiospecific Silver-Catalyzed [3+2] Cycloaddition of Aryl-, Alkyl- and Aminosulfonyl Diazomethanes with Arenediazonium Tosylates

7 July, 2020 - 00:00

A AgI-catalyzed [3+2] cycloaddition between diazomethyl sulfones and sulfonamides with arenediazonium tosylates provides regiospecific access to novel tetrazoles. The reaction products can be obtained in moderate to good yields.

[Communications]
Ekaterina Levashova, Dr. Olga Bakulina, Prof. Dr. Dmitry Dar'in, Andrey Bubyrev, Sergey Chuprun, Prof. Dr. Mikhail Krasavin
doi.org/10.1002/ejoc.202000619

Metal-Catalyzed Regiospecific (4+3) Cyclization of 2-Indolylmethanols with <i>ortho</i>-Quinone Methides

7 July, 2020 - 00:00

The first metal-catalyzed C3-nucleophilic (4+3) cyclization of 2-indolylmethanols with stable ortho-quinone methides has been established, which was used to construct indole-based seven-membered heterocycles in high yields (up to 98 %) with regiospecificity.

[Full Papers]
Si-Jia Zhou, Meng Sun, Jing-Yi Wang, Xian-Yang Yu, Han Lu, Prof. Dr. Yu-Chen Zhang, Prof. Dr. Feng Shi
doi.org/10.1002/ejoc.202000693

Total Synthesis of the Antitumor Depsipeptide FE399 and Its S-Benzyl Derivative: A Macrolactamization Approach

7 July, 2020 - 00:00

The total synthesis of a novel antitumor cyclic depsipeptide FE399 was achieved mainly through the MNBA-mediated macrolactamization. A combination of MNBA and a catalytic amount of DMAPO in the presence of triethylamine as coupling agents was found to be effective for the synthesis of the macrolactam core of FE399.

[Communications]
Dr. Takayuki Tonoi, Miyuki Ikeda, Teruyuki Sato, Takehiko Inohana, Ryo Kawahara, Dr. Takatsugu Murata, Prof. Dr. Isamu Shiina
doi.org/10.1002/ejoc.202000459

Facile Synthetic Route to [3.n]Thiacyclophanes through Ring-Closing Metathesis and their Structural Studies

7 July, 2020 - 00:00

Here, we are reporting a simple synthetic strategy for the synthesis of thiacyclophanes by using the Grignard reaction and ring-closing metathesis as key steps. The structures are confirmed by single-crystal XRD diffraction studies and compared with computationally optimized structures.

[Full Papers]
Prof. Sambasivarao Kotha, Naveen Kumar Gupta, Saima Ansari
doi.org/10.1002/ejoc.202000697

Rhodium-Catalyzed Reductive Esterification Using Carbon Monoxide as a Reducing Agent

7 July, 2020 - 00:00

A rhodium-catalyzed reductive esterification of carboxylic acids with carbonyl compounds was developed. This protocol fits a variety of carboxylic acids and aldehydes, opening the short way from industrial bulk compounds to valuable esters.

[Communications]
Vladimir S. Ostrovskii, Dr. Sofiya A. Runikhina, Dr. Oleg I. Afanasyev, Dr. Denis Chusov
doi.org/10.1002/ejoc.202000438

Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

25 June, 2020 - 00:00

Peptide aldehyde production : An aldehyde-releasing reductase (R) domain has been identified as part of a minimal nonribosomal peptide synthetase (NRPS) in X. indica . We also show that the R domain from the tilivalline-producing NRPS can be used in engineered synthetases to introduce an aldehyde group and subsequently produce natural and unnatural pyrazinones.

[Communications]
Andreas Tietze, Dr. Yan-Ni Shi, Dr. Max Kronenwerth, Prof. Dr. Helge B. Bode
doi.org/10.1002/cbic.202000176

Thiol-Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers

25 June, 2020 - 00:00

It takes two : Pyridyl-disulfide (Py−Ds) conjugated non-ionic nontoxic polymers exhibit cellular uptake by thiol-disulfide exchange with exofacial cell-surface thiols without going through the endocytosis pathway. Control experiments establish essential role of the Py−Ds group as neither pyridine- nor an aliphatic disulfide-appended polymer shows similar cellular uptake.

[Communications]
Raju Bej, Arijit Ghosh, Dr. Jayita Sarkar, Dr. Benu Brata Das, Prof. Dr. Suhrit Ghosh
doi.org/10.1002/cbic.202000303

Conformational Selection as the Driving Force of Amyloid β Chiral Inactivation

25 June, 2020 - 00:00

Rippled upon reflection : Aβ-CI has been proposed to operate by forming rippled cross-β networks upon mixing of Aβ enantiomers, but the drastic kinetic effects are yet to be explained. DFT calculations showed that individual peptide strains adopt lower-strain conformations in rippled than in pleated cross-β sheets, thus suggesting that conformation selection is responsible for the observed kinetic effects.

[Full Papers]
Prof. Jevgenij A. Raskatov
doi.org/10.1002/cbic.202000237

Cu-Catalyzed Reductive <i>gem </i>-Difunctionalization of Terminal Alkynes via Hydrosilylation/Hydroamination Cascade: Concise Synthesis of α-Aminosilanes

25 June, 2020 - 00:00

Si(lent) N(ight) in alkyne : A Cu/TMS-dppbz-catalyzed hydrosilylation/hydroamination cascade of simple terminal alkynes with hydrosilanes and hydroxylamines proceeds chemoselectively to deliver the reductive gem -difunctionalization products, α-aminosilanes, in a single operation. Additionally, the chiral (R ,R )-Ph-BPE ligand makes the reaction asymmetric to directly form the corresponding optically active α-aminosilanes, which are Si mimics of enantioenriched α-amino acids and of interest in medicinal chemistry.

[Communications]
Soshi Nishino, Prof. Dr. Koji Hirano, Prof. Dr. Masahiro Miura
doi.org/10.1002/chem.202001799

Enantiomerically Pure Tetravalent Neptunium Amidinates: Synthesis and Characterization

25 June, 2020 - 00:00

Enantiopure transuranic complexes : The first structurally characterized enantiopure complexes of neptunium have been synthesized. Starting from a chloro tris(amidinate) complex unprecedented neptunium(IV) fluoro, -bromo and -azido compounds could be yielded and characterized in solution and in the solid state (see scheme).

[Communications]
Sebastian Fichter, Sebastian Kaufmann, Dr. Peter Kaden, Dr. Tobias S. Brunner, Prof. Dr. Thorsten Stumpf, Prof. Dr. Peter W. Roesky, Dr. Juliane März
doi.org/10.1002/chem.202001865

Electro-Olefination—A Catalyst Free Stereoconvergent Strategy for the Functionalization of Alkenes

25 June, 2020 - 00:00

Electro-Olefination : The electrocoupling between (hetero)aryls and alkenes by alkenyl-triaryl borates (ATBs) is demonstrated. ATBs are synthesized by a triple ligand exchange reaction on potassium alkenyltrifluroborates with organometallic species and directly oxidized in an electrochemical two-pot coupling towards functionalized alkenes in a stereoconvergent fashion.

[Communications]
Andreas N. Baumann, Arif Music, Jonas Dechent, Nicolas Müller, Dr. Thomas C. Jagau, Dr. Dorian Didier
doi.org/10.1002/chem.202001394

Reversible <i>N- </i>Heterocyclic Carbene-Induced α-H Abstraction in Tungsten(VI) Imido Dialkyl Dialkoxide Complexes

25 June, 2020 - 00:00

Time to say good bye : The N -heterocyclic carbene-induced α-H elimination in tungsten(VI) imido dialkyl dialkoxide complexes offers access to tungsten(VI) imido alkylidene monoalkyl monoalkoxide complexes in excellent yields of up to 96 %.

[Communications]
Janis V. Musso, Mathis J. Benedikter, Dr. Dongren Wang, Dr. Wolfgang Frey, Hagen J. Altmann, Prof. Dr. Michael R. Buchmeiser
doi.org/10.1002/chem.202000840

Monohydride-Dichloro Rhodium(III) Complexes with Chiral Diphosphine Ligands as Catalysts for Asymmetric Hydrogenation of Olefinic Substrates

25 June, 2020 - 00:00

Curious cats : Asymmetric hydrogenation of simple olefins was achieved by using monohydride-dichloro rhodium(III) complexes 1 a -c which were characterized by NMR spectroscopy, including DOSY NMR, and X-ray single crystal analysis. Among these three complexes, 1 c has a rigid pocket surrounded by two chloride atoms bound to the rhodium atom for fitting to simple olefins without any coordinating functional groups.

[Full Papers]
Dr. Kosuke Higashida, Fabian Brüning, Nagataka Tsujimoto, Kenya Higashihara, Dr. Haruki Nagae, Prof. Dr. Antonio Togni, Prof. Dr. Kazushi Mashima
doi.org/10.1002/chem.202000542

Electronic Consequences of Ligand Substitution at Heterometal Centers in Polyoxovanadium Clusters: Controlling the Redox Properties through Heterometal Coordination Number

25 June, 2020 - 00:00

Combined experimental and theoretical methods are used to gain fundamental understanding of the redox-properties of iron-vanadium oxo-alkoxide clusters as they related to modification of the heterometal number.

[Full Papers]
Rachel L. Meyer, Dr. Montaha H. Anjass, Brittney E. Petel, Dr. William W. Brennessel, Prof. Carsten Streb, Prof. Ellen M. Matson
doi.org/10.1002/chem.201905624

Site-Directed Antibody Immobilization by Resorc[4]arene-Based Immunosensors

25 June, 2020 - 00:00

The immobilization of antibodies for optimized immunosensor development has been obtained by using resorc[4]arene as site-directing tool; this makes it possible to overcome the complexity of binding an antibody to the sensor surface, avoiding the random orientation with a lower binding site density and immunoaffinity. A surface plasmon resonance (SPR) technique has been employed for the characterization of the modified surface as well as to evaluate the heterogeneous kinetics of the model insulin/insulin-Ab interaction.

[Full Papers]
Dr. Deborah Quaglio, Laura Mangiardi, Dr. Giulia Venditti, Cristina Del Plato, Francesca Polli, Dr. Francesca Ghirga, Prof. Gabriele Favero, Prof. Marco Pierini, Prof. Bruno Botta, Prof. Franco Mazzei
doi.org/10.1002/chem.202000989

Photophysics, Electrochemistry and Efficient Electrochemiluminescence of Trigonal Truxene-Core Dyes

25 June, 2020 - 00:00

A series of new dyes built from a spirofluorene or truxene core connected to terminal donor groups via π-conjugated linkers having thiophene moieties has been synthesized and studied. Electrochemistry indicates the formation of stable radical cations and anions related to the charge delocalization. The brightest ECL emission is obtained with the blue-emitting truxene dye by annihilation and the coreactant pathway.

[Full Papers]
Dr. Silvia Voci, Prof. Jean-Baptiste Verlhac, Dr. Federico Polo, Guillaume Clermont, Dr. Jonathan Daniel, Prof. Frédéric Castet, Dr. Mireille Blanchard-Desce, Prof. Neso Sojic
doi.org/10.1002/chem.202000474

Engineering Bifunctional Host Materials of Sulfur and Lithium-Metal Based on Nitrogen-Enriched Polyacrylonitrile for Li-S Batteries

25 June, 2020 - 00:00

Polyacrylonitrile (PAN) is delicately engineered as a bifunctional host material to simultaneously solve the problems of the shuttle effect in the cathode and lithium dendrite in the anode, which leads to improved electrochemical performances of both electrodes. Due to excellent bifunctional host characteristics, the full cell demonstrates an outstanding long-term cycling capability.

[Full Papers]
Zudian Dai, Mei Wang, Yin Zhang, Boya Wang, Hang Luo, Xuemei Zhang, Dr. Qian Wang, Prof. Yun Zhang, Prof. Hao Wu
doi.org/10.1002/chem.202000467

Activity-Based Sensing of Ascorbate by Using Copper-Mediated Oxidative Bond Cleavage

25 June, 2020 - 00:00

Probing ascorbate : A new, activity-based sensing strategy was developed for the highly selective detection of ascorbate. A copper(II) complex was designed to be activated by ascorbate to effect an oxidative bond cleavage and release an emissive fluorophore for a turn-on signal. The new ascorbate probes can be applied in complex matrix including food, plasma, and live cells.

[Full Papers]
Zuo Hang Yu, Christopher J. Reinhardt, Thomas Hin-Fung Wong, Ka Yan Tong, Prof. Jefferson Chan, Dr. Ho Yu Au-Yeung
doi.org/10.1002/chem.202000780

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